WebJun 1, 2024 · Abstract. BRCA1-associated protein 1 (BAP1) is emerging as an intensively studied cancer-associated gene. Germline mutations in BAP1 lead to a cancer syndrome, and somatic loss is found in several cancer types. BAP1 encodes a deubiquitinase enzyme, which plays key roles in cell-cycle regulation, cell death, and differentiation. Recent … WebApr 26, 2024 · A conventional CCRCC component was frequently present adjacent to the characteristic BAP1 areas and showed retained BAP1 expression and only patchy …
US11613786B2 Clonal haematopoiesis - patentguru.com
WebApr 12, 2024 · Lung cancer is the leading cause of cancer-associated mortality worldwide1. Here we analysed 1,644 tumour regions sampled at surgery or during follow-up from the first 421 patients with non-small ... WebIn contrast, all 42 ATs showed retained BAP1 immunoreactivity. Notably, all 4 MM cases with variable adenomatoid-like features were BAP1-deficient. Surface components of … hematin crystal image
Novel insights into the BAP1 -inactivated melanocytic tumor
Web31 levels showed a better prognosis compared to the ones with BAP1 retained/high miR-31 levels (median OS 22.6 vs. 17.0 months, P=0.017 and median PFS 8.7 vs. 5.1 months, P=0.020). The BAP1 and miR-31 combination was confirmed at multivariate analysis as an independent prognostic factor for e-MPM patients. WebJun 23, 2024 · Thus, CDKN2A FISH can be performed in challenging mesothelial lesions with retained BAP1, although CDKN2A FISH reportedly occurs in only 52–68% of mesotheliomas [5, 10, 18,19,20,21,22]. WebAug 13, 2014 · It is interesting that one of the mutants known to increase the catalytic activity of BAP1, S63C, retained the same ability to relocalize to the damaged area as the WT protein . In a control experiment, we showed that all the GFP-BAP1 constructs expressed to a similar degree . These results indicate that BAP1 recruitment at sites of DNA damage ... hematin aip