WebJun 30, 2024 · Forkhead box M1 (FOXM1) was initially shown to sustain cell proliferation by regulating cell cycle progression. 3 Four FOXM1 isoforms, FOXM1A/B/C/D, have been identified due to alternative... FOXM1 is known to play a key role in cell cycle progression where endogenous FOXM1 expression peaks at S and G2/M phases. FOXM1-null mouse embryos were neonatal lethal as a result of the development of polyploid cardiomyocytes and hepatocytes, highlighting the role of FOXM1 in mitotic division. … See more Forkhead box protein M1 is a protein that in humans is encoded by the FOXM1 gene. The protein encoded by this gene is a member of the FOX family of transcription factors. Its potential as a target for future cancer treatments … See more FOXM1 gene is now known as a human proto-oncogene. Abnormal upregulation of FOXM1 is involved in the oncogenesis of basal cell carcinoma, … See more The exact mechanism of FOXM1 in cancer formation remains unknown. It is thought that upregulation of FOXM1 promotes oncogenesis through abnormal impact on its multiple roles in … See more Given the role in progenitor/stem cells expansion, FOXM1 has been shown to modulate the epigenome. It was found that overexpression of … See more There are three FOXM1 isoforms in humans, A, B and C. Isoform FOXM1A has been shown to be a gene transcriptional repressor whereas the remaining isoforms (B and C) are both transcriptional activators. Hence, it is not surprising that … See more A recent report by the research group which first found that the over-expression of FOXM1 is associated with human cancer, showed that aberrant upregulation of FOXM1 in adult human epithelial stem cells induces a precancer phenotype in a 3D-organotypic … See more FOXM1 has been shown to interact with Cdh1. See more
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WebApr 7, 2024 · FoxM1 is a pro-proliferation transcription factor. It stimulates expression of genes important for G1 to S progression, as well as mitotic … WebRecognizes human FOXM1b, C-terminal. Suitable for Immunohistochemistry and Immunoprecipitation applications. Forkhead box protein M1 is a member of the FOX family of proteins involved in gene expression specifically transcription factors. It is an important protein in cell cycle where endogenous FOXM1 expression peaks at S and G2/M phases. impact lx88 keyboard
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WebApr 7, 2024 · FoxM1b is a cell cycle-regulated transcription factor, whose over-expression is a marker for poor outcome in cancers. Its transcriptional activation function requires … WebOct 22, 2009 · Here we report that Foxm1b is the first direct farnesoid X receptor (FXR) target gene known to be involved in cell cycle regulation and that aging regenerating livers have delayed activation of FXR, which results in defective induction of Foxm1b and thereby contributes to defective liver regeneration. An inverted repeat 0 (IR-0) FXR response ... WebSep 18, 2003 · FoxM1B (previously named HFH-11, WIN or Trident) is a member of the Forkhead box (Fox) transcription factor family, whose members play important roles in regulating embryogenesis, cellular... impact mabel park