Phosphatase tensin-type domain

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August undefined, 2024

Web132 rows · Apr 4, 2024 · Summary. This gene encodes a phosphatase with dual activity against phospholipids and proteins, and acts as a tumor-suppressor. The protein contains … WebAug 26, 2024 · The importance of phosphatase and tensin homolog deleted on chromosome ten ( PTEN) in tumorigenesis is underscored by its frequent mutations, including missense, nonsense, frameshift, and large...

PTENα functions as an immune suppressor and …

WebSMART: PTEN_C2 domain annotation PTEN_C2 C2 domain of PTEN tumour-suppressor protein There are 6056 PTEN_C2 domains in 6045 proteins in SMART's nrdb database. Click on the following links for more information. Evolution (species in which this domain is found) Cellular role (predicted cellular role) Structure (3D structures containing this domain) WebBreast cancer has been attributed to be the second most common malignancy in females worldwide after skin cancer associated with a significantly high mortality rate. Tumor suppressor genes have an indispensable role in maintaining genomic integrity how is tv brightness measured

Tensins – emerging insights into their domain functions, biological …

WebTensins constitute an eukaryotic family of lipid phosphatases that are defined by the presence of two adjacent domains: a lipid phosphatase domain and a C2-like domain. The … WebJul 27, 2015 · PTEN is composed of four structural domains [PIP2-binding domain (aa 1–13), a catalytic tensin-type phosphatase domain (aa 14–185), a C2 tensin-type domain, which binds phospholipids (aa 190–350), the carboxy-terminal tail of the protein (aa 350–400), and a PDZ-binding domain (aa 401–403). WebPhosphatase and tensin homolog (PTEN) is a tumor suppressor and component of PI3K-AKT-mTOR signaling. Cowden syndrome is an inherited, autosomal dominant phenotype … how is tv viewership determined

Interactions of phosphatase and tensin homologue (PTEN ... - Pub…

SMART: PTEN_C2 domain annotation

WebIPR014020 - Tensin_phosphatase_C2-dom Pfam Domains: PF08416 - Phosphotyrosine-binding domain PF10409 - C2 domain of PTEN tumour-suppressor protein PF00017 - SH2 … how is tv advertising effectivePhosphatase and tensin homolog (PTEN) is a phosphatase in humans and is encoded by the PTEN gene. Mutations of this gene are a step in the development of many cancers, specifically glioblastoma, lung cancer, breast cancer, and prostate cancer. Genes corresponding to PTEN (orthologs) have been … See more PTEN protein acts as a phosphatase to dephosphorylate phosphatidylinositol (3,4,5)-trisphosphate (PtdIns (3,4,5)P3 or PIP3). PTEN specifically catalyses the dephosphorylation of the 3` phosphate of the See more The structure of the core of PTEN (solved by X-ray crystallography, see figure to the upper right ) reveals that it consists primarily of a phosphatase domain, and a C2 domain: the phosphatase domain contains the active site, which carries out the See more PTEN inhibitors Bisperoxovanadium compounds may have a neuroprotective effect after CNS injury. PTEN is inhibited by See more PTEN (gene) has been shown to interact with: • CSNK2A2, • CSNK2A1, • MAGI3 • MVP, • NEDD4, See more Cancer PTEN is one of the most commonly lost tumor suppressors in human cancer; in fact, up to 70% of men with prostate cancer are estimated to have lost a copy of the PTEN gene at the time of diagnosis. A number of studies … See more Cell lines with known PTEN mutations include: • prostate: LNCaP, PC-3 • kidney: 786-O • glioblastoma: U87MG • breast : MB-MDA-468, BT549 See more • Multiple hamartoma syndrome See more how is tvc derived from mc schedule

"WebAug 26, 2024 · The importance of phosphatase and tensin homolog deleted on chromosome ten ( PTEN) in tumorigenesis is underscored by its frequent mutations, … " - Phosphatase tensin-type domain

Phosphatase tensin-type domain

WebMar 1, 2024 · β-Amyloid Precursor Protein Intracellular Domain Controls Mitochondrial Function by Modulating Phosphatase and Tensin Homolog-Induced Kinase 1 Transcription in Cells and in Alzheimer Mice Models Overall, we delineate a molecular cascade presenilins-AICD-Forkhead box O3a linking parkin to Pink-1. WebJul 5, 2005 · Domain: 431-573: C2 tensin-type InterPro annotation. BLAST Add. ... PTHR12305 PHOSPHATASE WITH HOMOLOGY TO TENSIN 1 hit; PTHR12305:SF60 …

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WebJun 27, 2006 · The pathology involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain. PARK19A is characterized by onset of parkinsonian symptoms in the first or second decade of life. WebProteins known to contain a phosphatase and a C2 tensin-type domain are listed below: Tensin, a focal-adhesion molecule that binds to actin filaments. It may be involved in cell …

WebGene Variant Descriptions. PTEN D24H lies within the phosphatase tensin-type domain of the Pten protein (UniProt.org). D24H results in reduced phosphatase activity in a yeast assay ( PMID: 29706350 ), and results in abnormal cellular localization and loss of PI3K/AKT/MTOR pathway inhibition, as indicated by increased expression of S6rp in ... WebMar 21, 2024 · TNS3 (Tensin 3) is a Protein Coding gene. Diseases associated with TNS3 include Thyroid Tumor and Primary Syphilis . Among its related pathways are MET promotes cell motility and Signaling by Receptor Tyrosine Kinases . Gene Ontology (GO) annotations related to this gene include phosphatase activity . An important paralog of this gene is …

WebGene Variant Descriptions. PTEN H93Q lies within the phosphatase tensin-type domain of the Pten protein (UniProt.org). H93Q demonstrates Pten protein stability similar to wild-type protein ( PMID: 32350270, PMID: 32366478 ), however, results in a partial loss of ability to rescue spheroid formation ( PMID: 32366478 ), fails to suppress Akt ... WebJan 1, 2009 · Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is a tumor suppressor and bi-functional lipid and protein phosphatase. We report that the metabolic regulator pyruvate dehydrogenase kinase1 (PDHK1) is a synthetic-essential gene in PTEN-deficient cancer and normal cells.

WebApr 3, 2024 · PTEN phosphatase and tensin homolog Gene ID: 5728, updated on 3-Apr-2024 Gene type: protein coding Also known as: BZS; DEC; CWS1; GLM2; MHAM; TEP1; MMAC1; …

WebContains 1 phosphatase tensin-type domain. Domain. The C2 domain binds phospholipid membranes in vitro in a Ca(2+)-independent manner; this binding is important for its tumor suppressor function. Post-translational modifications. Constitutively phosphorylated by CK2 under normal conditions. Phosphorylated in vitro by MAST1, MAST2, MAST3 and STK11. how is tv screen measuredWebMar 1, 2001 · Protein PHOSPHATASE AND TENSIN HOMOLOG 1 1 publication ( AtPTEN1 1 publication ) Gene names Name PTEN1 1 publication ORF names MUL8.80 Imported Ordered locus names At5g39400 Imported Organism names Organism Arabidopsis thaliana (Mouse-ear cress) Taxonomic identifier 3702 NCBI Taxonomic lineage how is tweed madeWebMar 21, 2024 · PTEN is a multi-functional tumor suppressor that is very commonly lost in human cancer. Observed in prostate cancer, glioblastoma, endometrial, lung and breast … how is twister playedWebPTEN H93Y lies within the phosphatase tensin-type domain of the Pten protein (UniProt.org). H93Y demonstrates loss of phosphatase activity ( PMID: 10866302 , PMID: … how is twilight anesthesia administeredWebJan 2, 2024 · Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) encodes a 403-amino acid protein with an amino-terminal domain that shares sequence homology with the actin-binding protein tensin and the putative tyrosine-protein phosphatase auxilin.Crystal structure analysis of PTEN has revealed a C2 domain that binds to … how is twisted tea madeWebPhosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchanger factor 2 (PREX2) is a novel regulator of the small guanosine triphosphatase Rac, and has been observed to be implicated in human cancer by inhibiting the activity of phosphatase and tensin homolog (PTEN), thus upregulating the activity of the phosphoinositide 3-kinase (PI3K) signaling … how is twitch wifeWebContains 1 phosphatase tensin-type domain. 结构域 The C2 domain binds phospholipid membranes in vitro in a Ca(2+)-independent manner; this binding is important for its tumor suppressor function. how is twins conceived